Changes in peripheral B cell subsets under immunosuppressive therapy [Elektronische Ressource] / vorgelegt von Shaoxian Hu

Aus der Medizinischen Universitä tsklinik, Abteilung Rheumatologie und Klinische Immunologie der Albert-Ludwigs-Universitä t Freiburg i.Br. Changes in peripheral B cell subsets under immunosuppressive therapy INAUGURAL - DISSERTATION Zur Erlangung des Medizinischen Doktorgrades der Medizinischen Fakultä t der Albert-Ludwigs-Universitä t Freiburg i.Br. Vorgelegt 2004 Von Shaoxian Hu Geboren in Wuhan, China Dekan Prof. Dr. med. J. Zentner 1. Gutachter Prof. Dr. med. H.-H. Peter 2. Gutachter Prof. Dr. sc. nat. H. Pircher Jahr der Promotion 2004 本论文献给一贯支持我事业的家人和朋友 To my husband, Lisi Liu, my daughter, Yue Liu, and my parents I List of figures Figure 1 Cellular stages of B-cell development in bone marrow and secondary lymphoid organs………………………………… .……………………… .………………… 8 Figure 2 Density-gradient separation of lymphocytes on Ficoll………………… ..… .... 26 Figure 3 Schematic mechanism of FACS Calibur……………………………………… . 29 rdFigure 4 Time in months of B cell subset analysis after the last pulse CYC therapy in the 3 SLE treatment group……………………………………………………… ..………… .. 31 rdFigure 5 Cumulative dose and number of CYC pulses in the 3 treatment group.………… .... 31 Figure 6 Mean number and duration of immunosuppressive therapy before measuring B-cell ndsubsets of the 2 SLE group……………………………………………………… .