Cathepsin D [Elektronische Ressource] : design and characterisation of new in vitro and in vivo substrates applied to biological samples = Cathepsin D / vorgelegt von Daniel Bächle

Cathepsin D Design and characterisation of new in vitro and in vivo substrates applied to biological samples Cathepsin D Entwicklung und Charakterisierung von neuen in vitro und in vivo Substraten und deren Anwendung in biologischen Proben Dissertation der Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften 2005 vorgelegt von Daniel Bächle Tag der mündlichen Prüfung: 20.12.2005 Dekan: Prof. Dr. S. Laufer 1. Berichterstatter: Prof. Dr. U. Weser 2. Berichterstatter: Prof. Dr. S. Stevanovi ć ACKNOWLEDGEMENTS First of all I thank Hubert Kalbacher for making this work possible and for his outstanding engagement in leading young lives into the right direction. His comprehension for scientific as well as for everyday problems is remarkable. Thanks for all. The friendly and inspiring atmosphere hand in hand with scientific knowledge at the medical and natural sciences research centre helped a lot to finish this thesis. Namely E. Malenke, J. Gogel, C. Luber, J. Brandenburg, T. Burster, J. Beck, J. Schnaut, K. Lehnert, M. Reich, A. Dittmar, T. Rückrich, F. Kramer A. Lautwein and T. Herrmann took part in solving practical and personal problems. I really appreciate your engagement. For support during the run-up to this thesis I thank H.-G. Rammensee, G.