Biotransformation of the analgesic-antipyretic drugs metamizole and aminopyrine by genetically polymorphic enzymes [Elektronische Ressource] / von Salem Omran Ali Abdalla

Biotransformation of the Analgesic-Antipyretic Drugs Metamizole and Aminopyrine by Genetically Polymorphic Enzymes Von der Fakultät für Lebenswissenschaften der Technischen Universität Carolo-Wilhelmina zu Braunschweig zur Erlangung des Grades eines Doktors der Naturwissenschaften ( Dr. rer. nat.) genehmigte D i s s e r t a t i o n von Salem Omran Ali Abdalla aus Sokna, Libyen 1. Referent: Professor Dr. Ingo Rustenbeck 2. Referent: Professor Dr. Jürgen Brockmöller eingereicht am: 29. Juni 2007 mündliche Prüfung (Disputation) am: 27. September 2007 Druckjahr 2007 The work described here was performed in the period from July 2002 to April 2007 at the Department of Clinical Pharmacology, Georg-August University, Göttingen To my parents And my children Omran and Raian Table of Contents TABLE OF CONTENTS TABLE OF CONTENTS.......................................................................................................................................I LIST OF ABBREVIATIONS............................................................................................................................ III 1 INTRODUCTION ...............