Biosynthesis and function of biological pteridines [Elektronische Ressource] : structural studies on two molybdopterin containing aldehyde oxido-reductases, from Desulfovibrio desulfuricans ATCC 27774 and from Desulfovibrio gigas, and the GTP cyclohydrolase I on E. coli, responsible for the first step of the tetrahydropterin biosynthesis / Jorge Manuel Baeta Simões Rebelo

Max-Planck Institut für Biochemie Abteilung Strukturforschung Biosynthesis and function of biological pteridines Structural studies on two molybdopterin containing Aldehyde oxido-reductases, from Desulfovibrio desulfuricans ATCC 27774 and from Desulfovibrio gigas, and the GTP cyclohydrolase I on E. coli, responsible for the first step of the tetrahydropterin biosynthesis. Jorge Manuel Baeta Simões Rebelo Vollständiger Abdruck der von der Fakultät für Chemie der Technische Universität München zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigten Dissertation. Vorsitzender: Univ.-Prof. Dr. Dr. Adelbert Bacher Prüfer der Dissertation: 1. apl.-Prof. Dr. Dr. h. c. Robert Huber 2. Univ.-Prof. Dr. Johannes Buchner Die Dissertation wurde am 7.6.2004 bei der Technischen Universität München eingereicht und durch die Fakultät für Chemie am 28.7.2004 angenommen. This work, although a valid scientific work, is nevertheless far from deserving an important scientific prize, but is a very important step on my life! Unfortunately this long step is under my personal aspirations, but is simply what was possible and nothing more. I will take the responsibility and the consequences for this damage. I will mainly address thanks to my supervisors, Professors Maria João Romão and Robert Huber and also to Professor Adelbert Bacher, those who made this work possible.