Biomarker discovery for psychiatric disorders [Elektronische Ressource] : insights from quantitative proteomics studies in animal models / vorgelegt von Michaela Filiou

Biomarker discovery for psychiatric disorders: Insights from quantitative proteomics studies in animal models Dissertation der Fakultät für Biologie der Ludwig-Maximilians-Universität München vorgelegt von Michaela Filiou München, Juli 2010 .. , .. To my beloved parents Erstgutachter: Prof. Dr. Rainer Landgraf Zweitgutachter: Prof. Dr. George Boyan Tag der mündlichen Prüfung: 15 Dezember 2010 Abstract ________________________________________________________________________ Abstract Although psychiatric disorders are among the leading causes of disability in modern societies, no molecular biomarkers exist for their accurate diagnosis, classification and treatment efficacy assessment. Proteomics technologies provide useful tools for identifying protein markers related to disease pathophysiology. To unravel the neurobiological underpinnings and identify candidate biomarkers for anxiety disorders, we interrogated the mouse model of high (HAB), normal (NAB) and low (LAB) anxiety-related behavior by a combined quantitative proteomics and metabolomics approach.