Bioinspired fabrication of biosilica-based bone substitution materials [Elektronische Ressource] / Filipe André da Silva Raminhos Natálio

Bioinspired fabrication of biosilica-basedbone substitution materialsDissertationzur Erlangung des GradesDoktor der Naturwissenschaftenim Promotionsfach ChemieAm Fachbereich Chemie, Pharmazie und Geowissenschaftender Johannes Gutenberg-Universitätin MainzFilipe André da Silva Raminhos Natáliogeb. in Caldas da Rainha (Portugal)Mainz, 18.12.2009Tag der mündlichen Prüfung: 13.07.2010Index1. Summary/Zusammenfassung………………………………………………………..82. Introduction2.1. Biomineralization…………………………………………………………..………132.2. Sponges as Eumetazoa: A long pathway…………………………………………152.3. Biomineralization in sponges……………………………………………………...172.3.1. Geological background……………………………………………………172.3.2. Biosilification in spicules…………………………………………………182.3.2.1. Structural features………………………………………………182.3.2.2. Biochemical approach…………………………………………..192.3.2.3. Silicatein – Silica polymerizing protein…………………………202.3.2.4. Spiculogenesis…………………………………………………...222.4. Silicatein wide applications..……………………………………….……………...262.4.1. Bionanotechnological applications of silicatein…………………………..262.4.2.Biomedical approach………………………………………………………302.5. Calcium Phosphate biominerals………………………………………………….322.5.1. Bone………………………………………………………………………322.5.1.1. Bone has functional biomineral in animal evolution…………...322.5.1.2. Bone hierarchial composition…………………………………..332.5.1.2. Bone biomineralization…………………………………………362.6. Tissue engineering………………………………………………………………...392.6.1.