Biochemical characterization of a novel lysosomal membrane protein disrupted in renal carcinoma 2 (DIRC2) [Elektronische Ressource] / submitted by Lalu Rudyat Telly Savalas

Biochemical Characterization of a Novel Lysosomal Membrane Protein Disrupted in Renal Carcinoma 2 (DIRC2) Dissertation in fulfillment of the requirement for the degree “Dr. rer. nat” of the Faculty of Mathematics and Natural Sciences at Kiel University submitted by Lalu Rudyat Telly Savalas Kiel 2011 Referees: 1. Prof. Dr. Paul Saftig 2. Prof. Dr. Matthias Leippe Date of oral examination : 13.05.2011 Approved for publication : 24.05.2011 Signed: Dean Herewith I declare that: 1. Apart from the supervisor`s guidance, the contents and design of this dissertation are my own work. 2. This thesis has not been in partially or wholly as part of a doctoral degree to another examining body. Parts of this work have been submitted for scientific publication 3. This thesis has been prepared according to the Rules of Good Scientific Practice of the German Research Foundation. Kiel, March 9, 2011 Lalu Rudyat Telly Savalas Acknowledgement I would like to thank to Prof. Dr. Paul Saftig and Dr. Bernd Schroeder who guided me throughout my PhD thesis. I would like to express my grateful to the Saftig´s present and former members: Eeva-Liisa Eskelinen, Karine Reiss, Seenu, Beimi, Marc, Alex, Christina Wehling, Marion, Jenny, Kathi, Micha, Judith, Marlies, Inez, Fr.