Biochemical and functional characterization of RhoSAP [Elektronische Ressource] : a RhoGAP of the postsynaptic density / eingereicht von Janine Dahl

Institut für Anatomie and Zellbiologie Direktor: Professor Dr. med. Tobias M. Böckers Biochemical and functional characterization of RhoSAP: A RhoGAP of the postsynaptic density Dissertation zur Erlangung des Doktorgrades Dr. biol. hum. der Medizinischen Fakultät der Universität Ulm Eingereicht von: Janine Dahl aus Ludwigslust 2008 Dekan: Prof. Dr. med. Klaus-Michael Debatin Erster Gutachter: Prof. Dr. med. Tobias M. Böckers Zweiter Gutachter: Prof. Dr. rer. nat. Dietmar Fischer Tag der Promotion: Abstract Biochemical and functional characterization of RhoSAP: A Rho GAP of the postsynaptic density By Janine Dahl Ulm University Glutamatergic synapses in the central nervous system are characterized by an electron dense network of proteins underneath the postsynaptic membrane including cell adhesion molecules, cytoskeletal proteins, scaffolding and adaptor proteins, membrane bound receptors and channels, G-proteins and a wide range of different signalling modulators and effectors. This so called postsynaptic density (PSD) resembles a highly complex signaling machinery.