Biochemical and functional characterization of Fyn-PAG association and its role in T-cell anergy [Elektronische Ressource] / von Michal Smida

Biochemical and functional characterization of Fyn-PAG association and its role in T-cell anergy Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) genehmigt durch die Fakultät für Naturwissenschaften der Otto-von-Guericke-Universität Magdeburg von Dipl.-Biol. Michal Smida geb. am 01.02.1976 in Boskovice, Tschechien Gutachter: Prof. Dr. Burkhart Schraven Prof. Doreen Cantrell eingereicht am: 27. September 2007 verteidigt am: 27. Februar 2008 ACKNOWLEDGEMENT Acknowledgement I am deeply thankful to my mentor, Dr. Jonathan A. Lindquist, for his invaluable scientific advice and professional guidance that lead me throughout the whole project. He was more than a simple supervisor of my PhD thesis; he really took care of my life, not only professionally but also privately. Not only did he gave me all the knowledge what was in his might, but he also had that rare gift of providing me with the necessary motivation and encouragement. He always infected me with his never-ending enthusiasm and found a word of assurance when I was loosing my last hope. I would never have been able to perform this work without the intense support of Prof. Burkhart Schraven. His constant objective view on our experiments and inestimable suggestions helped me to walk the right way and not to get lost in unlikely explanations.