Biochemical and biophysical characterization of the human ethylmalonic encephalopathy non-heme sulfur (Fe)-dioxygenase ETHE1, and X-ray absorption spectroscopy applications and methods development [Elektronische Ressource] / presented by Marco Salomone-Stagni

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Science presented by Diploma-Biology (Laurea), Marco Salomone-Stagni Born in: Udine, Italy Oral-examination: 11.11.2010 Biochemical and Biophysical Characterization of the Human Ethylmalonic Encephalopathy non-Heme Sulfur [Fe]-Dioxygenase ETHE1, and X-ray Absorption Spectroscopy Applications and Methods Development Referees: Prof. Dr. Irmgard Sinning Dr. Andreas Ladurner To my parents and friends Preface This Thesis is based on the results presented in the following manuscripts: 1. Dominik Barthelme, Urte Scheele, Stephanie Dinkelaker, Adam Janoschka, Fraser MacMillan, Sonja-Verena Albers, Arnold J. M. Driessen, Marco S. Stagni, Eckhard Bill, Wolfram Meyer-Klaucke, Volker Schünemann and Robert Tampè Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1 Journal of Biological Chemistry, 2007 May 11; 282(19): 14598-607 2.