Biochemical analysis of the phosphatase domain of the human soluble epoxide hydrolase (sEH) [Elektronische Ressource] / Shirli Homburg

Biochemical Analysis of the Phosphatase Domain of the Human Soluble Epoxide Hydrolase (sEH) D i s s e r t a t i o n zur Erlangung des Grades „Doktor der Naturwissenschaften“ am Fachbereich Biologie der Johannes Gutenberg-Universität in Mainz Shirli Homburg geboren in Tel-Aviv Mainz 2010 Dekan: 1. Berichterstatter: 2. Berichterstatter: Tag der mündlichen Prüfung: Contents Acknowledgments ...................................................................................................... 1 Abbreviations.............................................................................................................. 2 1 Abstract ............................................................................................................... 3 2 Introduction.......................................................................................................... 7 2.1 Epoxides, epoxide hydrolases (EH) and xenobiotic Metabolism ............................................ 7 2.1.1. Epoxides................................................................................................................................. 7 2.1.2. Xenobiotic metabolism and Epoxide hydrolases ................................................................... 7 2.1.3. Members of the epoxide hydrolase family ............................................................................. 9 2.