Benchmark Dose Technical Guidance Document

DRAFT EPA/630/R-00/001
DO NOT CITE OR QUOTE October 2000
External Review Draft
Benchmark Dose Technical Guidance Document
NOTICE
THIS DOCUMENT IS A PRELIMINARY DRAFT. It has not been formally released by the
U.S. Environmental Protection Agency and should not at this stage be construed to represent
Agency policy. It is being circulated for comment on its technical accuracy and policy
implications.
Risk Assessment Forum
U.S. Environmental Protection Agency
Washington, DC 20460DISCLAIMER
This document is an external draft for review purposes only and does not constitute U.S.
Environmental Protection Agency policy. Mention of trade names or commercial products does
not constitute endorsement or recommendation for use.EXECUTIVE SUMMARY ......................................................v
I. INTRODUCTION ...........................................................1
A. Purpose of This Guidance Document .....................................1
B. Background .........................................................2
C. A Brief Review of Literature Relating to Benchmark Dose ....................8
1. Earlier uses of benchmark modeling in dose-response assessment ..........8
2. Properties of the Benchmark Dose ...................................8
3. Approaches to BMD Computation .................................10
4. General Discussions of Standards for the Benchmark Dose ..............12
II. BENCHMARK DOSE GUIDANCE ...........................................13
A. Data ...