Association between plasma levels of the soluble CD14 receptor of lipopolysaccharide and the C(-260)→T polymorphism in the promoter of the CD14 gene and coronary artery disease [Elektronische Ressource] : investigations in a large case-control study / Natalie Khuseyinova

Universität UlmAus der Abteilung Innere Medizin IILeiter: Prof. Dr. V. HombachAssociation Between Plasma Levels of theSoluble CD14 Receptor of Lipopolysaccharideand the C(–260)fiT Polymorphism in thePromoter of the CD14 Gene and CoronaryArtery Disease: Investigations in a Large Case-Control Study.Dissertation zur Erlangung des Doktorgrades der Medizinder Medizinischen Fakultät der Universität Ulmvorgelegt vonNatalie Khuseyinovaaus AshgabatTurkmenistan20021Amtierender Dekan: Prof. Dr. R. Marre1. Berichterstatter: Prof. Dr. W. Koenig2. Berichterstatter: Prof. Dr. T.SimmetTag der Promotion: 26.04.20022To my family with deep gratitude for its persistent support of my academicendeavours3Table of contents:Abbreviations and Acronyms.................................................................................. 61 Introduction....................................... 91.1 Coronary artery disease (CAD).................................................................... 91.1.1 Pathogenesis of CAD: cellular and molecular interaction ..................... 91.1.2 Classical risk factors for CAD............................. 111.1.3 CAD – an inflammatory process ......................................................... 151.1.4 Possible role of infectious agents in the pathogenesis of CAD........... 161.2 CD14 – major receptor for bacterial lipopolysaccharide............................. 181.2.1 Chemical structure and biological role of LPS .................