Approaches to analyse and interpret biological profile data [Elektronische Ressource] / von Matthias Scholz

Approaches to analyse and interpretbiological profile dataDissertationzur Erlangung des akademischen Gradesdoctor rerum naturalium– Dr. rer. nat. –eingereicht an derMathematisch-Naturwissenschaftlichen Fakult¨atder Universit¨at PotsdamvonMatthias ScholzArbeitsgruppe BioinformatikMax-Planck-Institut fur¨ Molekulare PflanzenphysiologiePotsdam, im Januar 2006Approaches to analyse and interpret biological profile dataMatthias ScholzPOTSDAMUNIVERSITYJanuary 2006· Potsdam· GermanySummaryThis thesis deals with the analysis of large-scale molecular data. It is focused on theidentification of biologically meaningful components and explains the potentials of suchanalyses to gain deeper insight into biological issues. Many aspects are discussed in-cluding component search criteria to obtain the major information in the data andinterpretation of components.The first chapter provides an introduction to the concepts of component extraction andbeyond. Starting with a biological motivation for component extraction and the prob-lems to identify ideal ones, it introduces many of the central ideas, such as criteria tofind highly informative components and the benefit of component analysis to discoverrelations among molecules and the impact of experimental factors, which will be dis-cussed at greater length in later chapters of this work.