Apoptotic and non-apoptotic death receptor signaling pathways and their regulation by cFLIP, cIAPs and RIP1 in the skin [Elektronische Ressource] / von Mike Hupe

Apoptotic and non-apoptotic death receptor signaling pathways and their regulation by cFLIP, cIAPs and RIP1 in the skin Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) genehmigt durch die Fakultät für Naturwissenschaften der Otto-von-Guericke-Universität Magdeburg von Diplom Biologe Mike Hupe geb. am 09.02.1980, Leipzig, Germany Gutachter: Prof. Dr. Martin Leverkus Prof. Dr. Harald Wajant eingereicht am: 22.06.2010 verteidigt am: 03.11.2010 1 Acknowledgements To: Dr. Peter Geserick, Dr. Philip Diessenbacher, Beate Kellert, Barbara Kehler, Maria Feoktistova, Shyam Kavuri and Prof. Martin Leverkus, Thank you very much. This thesis was supported by the DFG graduate program GRK 1167. I am very grateful to the members of the GRK, in particular to the two charis, Prof. Michael Naumann and Prof. Eckart D. Gundelfinger. 2 Summary The worldwide increasing incidence of skin-derived cancer and their diversity requires development of novel therapeutic strategies. The malignant melanoma, for example, is a highly aggressive cancer with the capacity to metastasize at early stages. Together with resistance to chemotherapeutic agents it results in overall poor prognosis of melanoma patients once metastasis has occurred.