Apoptoseresistenz und Vermeidung von Anti-Tumor-Immunität -zwei verwandte (?) Überlebensstrategien maligner Gliomzellen [Elektronische Ressource] = Resistance to apoptosis and escape from host immune surveillance - two related (?) survival mechanisms of malignant glioma cells / vorgelegt von Jörg Hinrich Wischhusen

Apoptoseresistenz und Vermeidung von anti-Tumor-Immunität – zwei verwandte (?) Überlebensstrategien maligner Gliomzellen Resistance to apoptosis and escape from host immune surveillance - two related (?) survival mechanisms of malignant glioma cells DISSERTATION der Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften 2004 vorgelegt von Jörg Hinrich Wischhusen 2 Tag der mündlichen Prüfung: 14. Oktober 2004 Dekan: Professor Dr. S. Laufer 1. Berichterstatter: Professor Dr. Michael Weller 2. Berichterstatter: Professor Dr. Hans-Georg Rammensee 3. Berichterstatter: Professor Dr. Peter H. Krammer 3 There are two rules for a good scientific presentation: 1.) Never tell everything you know... Accordingly, the projects summarized in this thesis sought to explore and possibly overcome human glioma cells´ resistance to apoptosis as well as their escape from host immune surveillance. Work from other areas to which I also contributed has been omitted (see attached reference list). 4 Proprietary Declaration The work presented here has been performed under the guidance of Prof. Dr. Michael Weller from January 2000 until May 2004 in the Department of Neurology at the University of Tübingen Medical School.