Antibody array for the detection of protein phosphorylation & localization and application to dissect activities of different signaling pathways [Elektronische Ressource] / von Lin Wang

Antibody Array for the Detection of Protein Phosphorylation & Localization and Application to Dissect Activities of Different Signaling Pathways Dissertation Zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) Vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller-Universität Jena Von Lin Wang from Jinan born March12,1964 TABLES OF CONTENTS 1 Introduction................................................................................................................................... 1 1.1 Antibody Array Technologies............................................................................................. 1 1.2 Protein Phosphorylation, Localization and Function....................................................... 2 1.3 Interaction Proteomics and Pathway Building.................................................................... 3 1.3.1 BMP2 Signalling ............................................................................................................. 4 1.3.2 The Effect of STI 571 on Cell Signalling ........................................................................ 9 1.4 Aim ...........................................................................................................