Analysis of tissue formation capacity by transplanted cells in a liver repopulation model and establishment of a preclinical preconditioning regimen for liver cell therapy [Elektronische Ressource] / Qinggong Yuan. Department of Gastroentology, Hepatology and Endocrinology Hannover Medical School. Betreuer: Michael Ott

Department of Gastroentology, Hepatology and Endocrinology Hannover Medical School Analysis of tissue formation capacity by transplanted cells in a liver repopulation model and establishment of a preclinical preconditioning regimen for liver cell therapy A thesis submitted for the degree of a Medical Doctor by Qinggong Yuan From Beijing, P.R. China Hannover 2010 Angenommen vom Senat der Medizineschen Hochschule Hannover am 08.02.2011 Gedruckt mit Genehmigung der Medizinischen Hochschule Hannover Präsident: Prof. Dr. Dieter Bitter-Suermann Betreuer: Prof. Dr. med. Michael Ott Referent: Prof. Dr. med. Anibh Martin Das Korreferent: Prof. Dr. med. Michael Winkler Tag der mündlichen Prüfung: 08.02.2011 Promotionsausschussmitglieder: Prof. Dr. Jürgen Klempnauer Prof. Dr. Benno Ure Prof. Dr. Johann Karstens Content Ⅰ Sumary 11. Liver cell therapy for the treatment of human liver diseases 1 2. The immunodeficient mouse liver repopulation model for standardised assessment of liver cell therapy 3 3. Cell numbers for liver cell therapy and repopulation efficacies in immunodeficient mice 3 4. Repopulation efficacies of various transplanted cell sources in alb-uPA mice 44.1. Primary mouse and human hepatocytes 4 4.2. Fetal liver progenitor cells 5 4.3. Embryonic stem cell-derived hepatocytes 6 5.