Analysis of the {TNFα-dependent [TNF-alpha-dependent] apoptosis - survival switch in hepatocytes by a systems biology approach [Elektronische Ressource] / vorgelegt von Kathrin Schmich

Analysis of the TNFα-dependent Apoptosis - Survival Switch in Hepatocytes by a Systems Biology Approach INAUGURALDISSERTATION zur Erlangung des Doktorgrades der Fakultät für Chemie, Pharmazie und Geowissenschaften der Albert-Ludwigs-Universität Freiburg im Breisgau vorgelegt von Kathrin Schmich aus Schweinfurt November 2010 Dekan: Prof. Dr. Harald Hillebrecht Leiterin der Arbeit: Prof. Dr. Irmgard Merfort Referentin: Prof. Dr. Irmgard Merfort Korreferentin: Prof. Dr. Regine Süss Drittprüfer: Prof. Dr. Christoph Borner Tag der Verkündigung des Prüfungsergebnisses: 03.02.2011 Parts of this work have been published in the following conference presentations and publications: Publications K. Naumann, K. Schmich, C. Jaeger, I.Merfort Noxa/Mcl-1 balance decides the effectiveness of MG132 with chemotherapeutics in pancreatic cancer In preparation * * † †R. Schlatter , K. Schmich , J. Trefzger, O. Sawodny, M. Ederer , I. Merfort †(* Both authors contributed equally to this work, shared senior authorship) Modeling the TNFα-induced apoptosis pathway in hepatocytes Submitted * *K. Schmich, R. Schlatter , N. Corazza , K. Sá Ferreira, M. Ederer, T. Brunner, C. Borner, I. Merfort (* Both authors contributed equally to this work) TNFα sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner Hepatology, 2010, Sept 24, ePub * *T. Sparna, J.