Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo [Elektronische Ressource] / presented by Caroline Ronzaud

DISSERTATION submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences Presented by Graduate Engineer in Biotechnology Caroline Ronzaud born in Echirolles, France thOral-examination: 19 of March 2007 Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo Referees: Prof. Dr. med. Günther Schütz Prof. Dr. Blanche Schwappach Table of contents TABLE OF CONTENTS 1. SUMMARY ...............................................................................................................................4 1. ZUSAMMENFASSUNG...........................................................................................................5 2. INTRODUCTION .....................................................................................................................7 2.1. The mineralocorticoid aldosterone...................................................................................7 2.2. The mineralocorticoid receptor ........................................................................................8 2.2.1. A member of the nuclear receptor family...........................................................8 2.2.2. Ligand binding specificity....................