Analysis of the role of estrogen receptor {α [alpha] in cerebral stroke [Elektronische Ressource] / presented by Joachim Elzer

DISSERTATION submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Biologe Joachim Elzer born in Heidelberg Oral examination: Analysis of the role of estrogen receptor α in cerebral stroke Referees: Prof. Dr. Günther Schütz Prof. Dr. Felix Wieland Contents I Contents Zusammenfassung.........................................................................1 Summary .......................................................................................3 1. Introduction ..........................................................................5 1.1 Estradiol ............................................................................. 5 1.2 Estradiol and stroke.............................................................. 8 1.3 Estrogen receptors ............................................................... 9 1.4 Estrogen receptor knock out mice..........................................10 1.5 Conditional mutagenesis.......................................................12 1.5.1 The Cre-loxP-system ......................................................12 1.6 Aim of this thesis.................................................................16 1.6.1 Endothelial cells of the vascular system: ..........