Analysis of the molecular mechanisms underlying the activity of the Ets-1-USF-1 transcription factor complex on the HIV-1 LTR [Elektronische Ressource] / presented by Ulrich Mayer

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Biologe: Ulrich Mayer born in: Hardheim Oral examination: 12th Mai, 2004 Analysis of the molecular mechanisms underlying the activity of the Ets-1/USF-1 transcription factor complex on the HIV-1 LTR Referees: PD, Dr. rer. nat. Gabriele Peterson PD, Dr. Michael Sieweke The work presented here was carried out in the laboratory of PD, PhD Michael Sieweke at the Centre d’Immunologie Marseille-Luminy (CIML) from August 2000 to Mai 2004. Analysis of the molecular mechanisms underlying the activity of the Ets-1/USF-1 transcription factor complex on the HIV-1 LTR Ulrich Mayer Summary To assure cell type specific gene transcription cells have developed strategies to control the transcription of a large number of genes with a limited number of transcription factors. This is achieved by combinatorial control in which a complex array of transcription factors regulates promoters and enhancers. Recognition of regulatory elements is governed by both protein-DNA and protein-protein interactions. Many transcription factors can engage in multiple protein-protein that form larger complexes required for adequate gene expression.