Analysis of the influence of epitope flanking regions on MHC class I restricted antigen presentation [Elektronische Ressource] / Alejandra Nacarino Martínez

U T O M N E S U N U M S I N T The SCHOOL OF MEDICINE and the DEPARTMENT OF BIOLOGY of the JOHANNES GUTENBERG-UNIVERSITY OF MAINZ confer on Alejandra Nacarino Martínez born on 22.10.1976 in Cádiz (Spain) in recognition of her dissertation “Analysis of the influence of epitope flanking regions on MHC class I restricted antigen presentation“ and the successful examinations the academic degree „Doktor der Naturwissenschaften" Mainz, 12.09.2007 Dean Department of Biology Day of the disputation: 07.12.2007 Index INDEX 1 INTRODUCTION 1 1.1 THE IMMUNE SYSTEM 1 1.2 INNATE IMMUNE RESPONSE 1 1.3 THE ADAPTIVE 2 1.3.1 Humoral immunity 2 1.3.2 Cell-mediated immunity 2 1.4 THE MHC COMPLEX 3 1.4.1 Structure of MHC molecules 4 1.4.2 Peptide binding on MHC molecules 4 1.5 MHC CLASS I ANTIGEN PROCESSING PATHWAY 5 1.5.1 The source of MHC class I peptides 5 1.5.2 ubiquitin-proteasome pathway 6 1.5.3 Peptide trimming by cytosolic aminopeptidases 6 1.5.3.1 Leucine aminopeptidase 7 1.5.3.2 Puromycin sensitive aminopeptidase & bleomycin hydrolase 7 1.5.3.3 Thimet oligopeptidase 8 1.5.3.4 Tripeptidyl peptidase II 1.5.3.5 Insulin degrading enzyme 9 1.5.4 Transport into the ER 10 1.5.4.