Analysis of the genetic potential of the spongederived fungus Penicillium chrysogenum E01-10/3 for polyketide production [Elektronische Ressource] / Marija Avramović

Analysis of the genetic potential of the sponge-derived fungus Penicillium chrysogenum E01-10/3 for polyketide production Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vorgelegt von Marija Avramovi ć aus Belgrad Bonn 2010 Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn 1. Gutachter: Prof. Dr. Jörn Piel 2. Gutachterin: Priv.-Doz. Dr. Gerhild van Echten-Deckert Tag der Mündlichen Prüfung: 16.02.2011 Erscheinungsjahr: 2011 To the unconditional love of my parents “In every job that must be done There is an element of fun You find the fun and snap! The job’s a game And every task you undertake Becomes a piece of cake A lark! A spree! It’s very clear to see that… A Spoonful of sugar helps the medicine go down The medicine go down Just a spoonful of sugar helps the medicine go down In a most delightful way… The honey bees that fetch the nectar From the flowers to the comb Never tire of ever buzzing to and fro Because they take a little nip From every flower that they sip And hence, They find Their task is not a grind …” “A spoon full of sugar”, Disney (Mary Poppins) Acknowledgements I want to thank my supervisor, Prof. Dr.