Analysis of the binding properties of the kinase C-RAF to mitochondria and characterization of its effects on the cellular and molecular level [Elektronische Ressource] = Untersuchung der Bindungseigenschaften der Kinase C-RAF an Mitochondrien und Charakterisierung der Effekte auf zellulärer und molekulare Ebene / submitted by Jochen Füller

Analysis of the binding properties of the kinase C-RAF to mitochondria and characterisation of its effects on the cellular and molecular level Untersuchung der Bindungseigenschaften der Kinase C-RAF an Mitochondrien und Charakterisierung der Effekte auf zellulärer und molekulare Ebene Doctoral thesis for submission to a doctoral degree at the Graduate School of Life Sciences, Julius Maximilian University Würzburg, Section Infection and Immunity submitted by Jochen Füller from Bamberg Würzburg, 2008 Submitted on: ……………………………………………………………. Office stamp Members of the Promotionskomitee: Chairperson: ………………………………………………………………… to be completed by the Office Primary Supervisor: Prof. Dr. UR Rapp Supervisor (second): Prof. Dr. R. Benz Supervisor (third): Day of Rigorosum: ………………………………………………………. Certificates were handed-out on: …………………………………….. Contents Contents Summary.............................................................................................................................. 6 Zusammenfassung............................................................................................................ 7 1. Introduction 1.1. RAF kinases as proto-oncogenes and signaling through the RAS-RAF-MEK-ERK cascade......................................................................................