Analysis of the arachidonyl-CoA synthetase ACSL4a as a potential regulator of BMP expression and of the role of BMPs in timing of cell commitment along the dorsoventral axis of the gastrulating zebrafish embryo [Elektronische Ressource] / vorgelegt von Björn Renisch

Analysis of the arachidonyl-CoA synthetase ACSL4a as a potential regulator of BMP expression and of the role of BMPs in timing of cell commitment along the dorsoventral axis of the gastrulating zebrafish embryo I n a u g u r a l - D i s s e r t a t i o n zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Universität zu Köln vorgelegt von Björn Renisch aus Bad Soden a. Ts. Köln, 2009 - 1 - Berichterstatter: Prof. Dr. Matthias Hammerschmidt Berichterstatter: Prof. Dr. Siegfried Roth Tag der mündlichen Prüfung: 27. November 2009 - 2 - Table of contents 1. Summary ................................................................................................................................ 6 1.2 Zusammenfassung ................................................................................................................ 8 2. General Introduction ............................................................................................................ 10 2.1. Early zebrafish development ......................................................................................... 10 2.2 The establishment of the dorsal-ventral axis in zebrafish .............................................. 12 2.3. The role of Bone Morphogenetic Proteins during gastrulation ..