Analysis of {γ-secretase [gamma-secretase] regulation by phosphatidylethanolamine using mammalian and Drosophila melanogaster in vitro and in vivo model systems [Elektronische Ressource] / presented by Iva Nesic

Dissertationsubmitted to theCombined Faculties for the Natural Sciences and forMathematics of the Ruperto-Carola University ofHeidelberg, Germanyfor the degree ofDoctor of Natural SciencesPresented by: Diplom-Biologin Iva NesicBorn in: BanjalukaAnalysis of -secretase regulation byphosphatidylethanolamine using mammalian andDrosophila melanogaster in vitro and in vivo modelsystemsReferees: Prof. Dr. Dr. h.c. Konrad BeyreutherProf. Dr. Werner BuselmaierIch widme diese Arbeit meinen Eltern.AcknowledgementsI would like to express my gratitude Prof. Dr. Carlos Dotti for giving me thepossibility to carry on this project in his group.I want to thank my supervisor Prof. Dr. Dr. h.c. Konrad Beyreuther for supportingme with his critical comments, his suggestions regarding my work and for givingme the possibility to make my doctoral thesis at the University of Heidelberg.I want to thank Sabine Paul, Prof. Dr. Jens Wiltfang and Dr. Laura Doglio for A!peptide measurements.I want to thank all the members of the Dotti and Beyreuther group: especially myfriends Cristian Galvan and Bianca Hellias for help and critics and for beingalways next to me, than Dr. Stefan Kins, Dr. Anita Szodorai and Dr. TomasGruebl for being present in emergency situations.Thank you very much Giulia for your support and for teaching me how to workwith flies.