Analysis of retinoblastoma protein function in the regulation of apoptosis [Elektronische Ressource] = Analyse der Funktion des Retinoblastoma-Proteins in der Apoptose-Regulation / von Anja Masselli

Analysis of retinoblastoma protein function in the regulation of apoptosis Analyse der Funktion des Retinoblastoma-Proteins in der Apoptose-Regulation Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller-Universität Jena von Diplom-Biochemikerin Anja Masselli geboren am 25.07.1976 in Göttingen Jena, 2005 Table of contents Table of contents 1 Introduction............................................................................................................1 1.1 Apoptosis as cell fate and cellular stress response............................................1 1.2 Central mediators of the apoptotic program......................................................2 1.3 The intrinsic apoptosis pathway........................................................................3 1.4 Death receptor-induced apoptosis .....................................................................6 1.5 Regulation of apoptosis pathways9 1.6 The retinoblastoma protein as a regulator of proliferation and apoptosis.......13 1.7 Objectives........................................................................................................17 2 Results ...................................................................................................................18 2.