Analysis of glucocorticoid receptor function in murine lung development using cell type-specific gene ablation [Elektronische Ressource] / presented by Daniel Habermehl

DISSERTATION submitted to the Combined Faculties for the Natural Sciences and for Mathematics Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Ernährungswissenschaftler Daniel Habermehl born in Lahn/Wetzlar thoral examination: April 24 , 2008 Analysis of glucocorticoid receptor function in murine lung development using cell type-specific gene ablation Referees: Prof. Dr. Günther Schütz Prof. Dr. Felix Wieland Table of contents Table of Contents 1. Summary........................................................................................1 2. Zusammenfassung .......................................................................2 3. Introduction ...................................................................................3 3.1. Development and structure of the murine respiratory system................. 3 3.1.1. Lung morphogenesis.................................................................................... 3 3.1.2. Cell types of the developing and mature distal lung and their functions....... 4 3.1.3. Epithelial-mesenchymal interactions in the developing lung ........................ 5 3.1.4. Glucocorticoid action during lung development............................................ 6 3.2. Glucocorticoids ...............................................................