Analysing the role of short stop during the formation of synaptic terminals in Drosophila melanogaster [Elektronische Ressource] / Michael Mende

“Analysing the Role of Short Stop during theFormation of Synaptic Terminals inDrosophila melanogaster”Dissertationzur Erlangung des GradesDoktor der NaturwissenschaftenAm Fachbereich BiologieDer Johannes Gutenberg-Universität MainzMichael MendeGeboren am 29.01.1974in Abidjan, ElfenbeinküsteMainz, März 2004Tag der mündlichen Prüfung: 07 Juni 2004INDEX I CHAPTER INDEX 1. INTRODUCTION_________________________________________________________ 1 1.1. Significance of synapses for the function of the nervous system______________________ 1 1.2. Problem leading up to this work ___________________________________________________ 3 1.3. Drosophila melanogaster as a model system for studying the cellular and molecular mechanisms of synaptic development_______________________________________________ 4 1.4. Short stop phenotypes and its relevance for synapse formation_______________________ 9 1.5. Aim of this study ________________________________________________________________ 12 2. MATERIALS AND METHODS ____________________________________________ 13 2.1. Fly genetics and Cellbiology _____________________________________________________ 13 2.1.1. Fly stock maintenance________________________________________________________ 13 2.1.2. Fly stocks ___________________________________________________________________ 13 2.1.3. Virgin collection and genetic crosses __________________________________________ 15 2.1.4.