An investigation into the involvement of cell adhesion molecules and perineurial cells in endogenous tissue repair following experimental spinal cord injury in the rat [Elektronische Ressource] / vorgelegt von Thomas Hermanns

An investigation into the involvement of cell adhesion molecules andperineurial cells in endogenous tissue repair following experimental spinal cord injury in the ratVon der Medizinischen Fakultätder Rheinisch-Westfälischen Technischen Hochschule Aachenzur Erlangung des akademischen Gradeseines Doktors der Medizingenehmigte Dissertationvorgelegt vonThomas HermannsausMönchengladbachBerichter: Herr ProfessorDr. med. Wilhelm NacimientoHerr UniversitätsprofessorDr. rer. nat. Dr. med. habil. Hubert KorrTag der mündlichen Prüfung: 19. September 2003“Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar”Table of contentsTable of contents1. Summary 12. Introduction 32.1. Traumatic spinal cord injury 32.2. Successful axonal regeneration in the peripheral nervous system (PNS) 42.2.1. The perineurium and the role of perineurial cells in peripheral nerve regeneration 62.3. Cellular and molecular mechanisms involved in the failure of CNS axonregeneration 9 2.3.1. Oligodendrocytes and central myelin 92.3.2. Astrocytes 102.3.3. Neurons: intrinsic state 112.4. Therapeutical strategies to enhance anatomical plasticity and recovery offunction after spinal cord injury 122.5. Endogenous tissue repair 152.6. The cell adhesion molecules L1 and N-CAM 16 2.6.1. L1 162.6.2. N-CAM 172.7. Hypotheses tested in the investigations 183. Material and Methods 203.1. Animals 203.2. Lesion models3.2.1.