Alzheimer disease [Elektronische Ressource] : identification and characterization of the putative binding partners of amyloid precursor protein (APP) and cell adhesion molecules as biochemical markers / vorgelegt von Elena Strekalova

Alzheimer disease: Identification and characterization of the putative binding partners of amyloid precursor protein (APP) and cell adhesion molecules as biochemical markers Dissertation zur Erlangung des Doktorgrades des Fachbereiches Biologie der Universität Hamburg vorgelegt von Elena Strekalova Hamburg, 2003 Name: Elena Strekalova Titel der Dissertation: Alzheimer disease: Identification and characterization of putative binding partners of amyloid precursor protein (APP) and cell adhesion molecules as biochemical markers Gutachter: Frau Prof. Dr. M. Schachner Herr Prof. Dr. L. Renwrantz I. INTRODUCTION.................................................................................................................1 1. ALZHEIMER DISEASE............................................................................................................1 1.1 Amyloid precursor protein............................................................................................2 1.2 Proteolytic processing of APP......................................................................................5 1.2.1 α-Secretase5 1.2.2 β.............................................................................................................6 1.2.3 γ-Secretase7 2. CELL ADHESION MOLECULES OF IMMUNOGLOBULIN SUPERFAMILY.....................................9 2.1 The cell adhesion molecule L1 ............................................