Active zone proteins Bassoon and Piccolo at the calyx of Held [Elektronische Ressource] : age - dependent localization and targeted in vivo perturbation / by Anna Dondzillo

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Masters in Biology Anna Dondzillo from Warsaw, Poland Oral-examination:_________________________________ Active zone proteins Bassoon and Piccolo at the calyx of Held: age - dependent localization and targeted in vivo perturbation Referees: Prof. Dr. Bert Sakmann Prof. Dr. Thomas Kuner I hereby declare that this submission is my own work and that, to the best of my knowledge and belief, it contains no material previously published or written by another person nor material which to a substantial extent has been accepted for the award of any other degree or diploma of the university or other institute of higher learning, except where due acknowledgment has been made in the text. Heidelberg, 27 November 2007 __________________________ Anna Dondzillo Active zone proteins Bassoon and Piccolo at the calyx of Held: age - dependent localization and targeted in vivo perturbation Summary Neurons communicate with each other via synaptic transmission. Chemical synapses transfer information through the release of neurotransmitter.