A macrophage migration inhibitory factor interactome screen identifies a complex of Jab1-CSN5 and valosin-containing protein as an important mediator in the ubiquitin proteasome system [Elektronische Ressource] / by Cayli Sevil

A Macrophage Migration Inhibitory Factor interactome screen identifies a complex of Jab1/CSN5 and Valosin-containing protein as an important mediator in the ubiquitin proteasome system Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfillment of the requirements for the PhD-Degree of the Faculty of Medicine of the Justus Liebig University Giessen by Cayli Sevil of Ankara, TURKEY Giessen (2008) From the Department of Anatomy and Cell Biology Director / Chairman: Prof. Dr. E. Baumgart-Vogt of the Faculty of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: Prof.Dr. Andreas Meinhardt Second Supervisor: Prof. Dr. Jürgen Bernhagen Committee Members: Prof. Dr. Dr. Hans Michael Piper, Privatdozent Dr. Sandip Kanse Date of Doctoral Defense: 24.09.2008 Contents CONTENTS 1. INTRODUCTION ................................................................................................................1 1.1. The history of MIF ..........................................................................................................1 1.2. MIF-mediated signaling pathways ..................................................................................2 1.2.1. MIF-mediated ERK1/ERK2 activation ....................................................................2 1.2.2.