A directed evolution design of target specificity and kinetic analysis of conformational transitions in the HhaI methyltransferase ; DNR metiltransferazės HhaI atpažįstamos sekos inžinerija ir konformacinių virsmų kinetikos tyrimas

VILNIUS UNIVERSITY INSTITUTE OF BIOTECHNOLOGY Rūta Gerasimaitė A DIRECTED EVOLUTION DESIGN OF TARGET SPECIFICITY AND KINETIC ANALYSIS OF CONFORMATIONAL TRANSITIONS IN THE HhaI METHYLTRANSFERASE Summary of doctoral dissertation Physical science, biochemistry (04 P) Vilnius, 2011 This study has been carried out at the Institute of Biotechnology during 200332009. Dissertation is maintained by extern. Scientific consultant Prof. habil. dr. Saulius Klimašauskas (Institute of Biotechnology, Vilnius University; physical sciences, biochemistry – 04 P) Evaluation board of dissertation of Biochemistry trend Chairman: Prof. habil. dr. Vida Mildažienė (Vytautas Magnus University; physical sciences, biochemistry – 04 P) Members: Prof. dr. Vilmantė Borutaitė (Institute for Biomedical Research, Lithuanian University of Health Sciences; physical sciences, biochemistry – 04 P) Dr. Daumantas Matulis (Institute of Biotechnology, Vilnius University; physical sciences, biochemistry – 04 P) Dr. Rolandas Meškys (Institute of Biochemistry, Vilnius University; physical sciences, biochemistry – 04 P) Dr. Gintautas Tamulaitis (Institute of Biotechnology, Vilnius University; physical sciences, biochemistry – 04 P) Official opponents: Habil. dr. arimantas Čėnas (Institute of Biochemistry, Vilnius University; physical sciences, biochemistry – 04 P) Dr.