Network architecture of the long-distance pathways in the macaque brain

Network architecture of the long-distance pathwaysin the macaque braina,1 bDharmendra S. Modha and Raghavendra Singha bIBM Research-Almaden, San Jose, CA 95120; and IBM Research-India, New Delhi 110070, IndiaCommunicated by Mortimer Mishkin, National Institute of Mental Health, Bethesda, MD, June 11, 2010 (received for review March 27, 2009)TogainabetterunderstandingofthestructureandorganizationUnderstandingthenetworkstructureofwhitemattercommunica-of the brain, a network spanning the entire brain would be ex-tion pathways is essential for unraveling the mysteries of thetremelyuseful.Suchanetworkwillbeanindispensablefoundationbrain’s function, organization, and evolution. To this end, we de-for clinical, systems, cognitive, and computational neurosciencesriveauniquenetworkincorporating410anatomicaltracingstudies(14). No such network has been reported. We undertake theofthemacaquebrainfromtheCollationofConnectivitydataonthechallenge of constructing, visualizing, and analyzing such a net-Macaquebrain(CoCoMac)neuroinformaticdatabase.Ournetworkwork.Ournetworkopensthedoortotheapplicationoflarge-scaleconsists of 383 hierarchically organized regions spanning cortex,network-theoretical analysis that has been so successful in un-thalamus,andbasalganglia;modelsthepresenceof6,602directedderstanding the Internet (15), metabolic networks, protein in-long-distanceconnections;isthreetimeslargerthananypreviouslyteractionnetworks(16),varioussocialnetworks(17) ...