The chemopreventive agent N hydroxyphenyl retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl family

The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family Patricia Boya1,8, Maria Celia Morales1,8, Rosa-Ana Gonzalez-Polo1, Karine Andreau1, Isabelle Gourdier1, Jean-Luc Perfettini1, Nathanael Larochette1, Aurelien Deniaud2, Fanny Baran- Marszak3, Remy Fagard4, Jean Feuillard5, Aintzane Asumendi6, Martine Raphael3, Bernard Pau7, Catherine Brenner2 and Guido Kroemer*,1 1Centre National de la Recherche Scientifique, UMR8125, Institut Gustave Roussy, Villejuif, France; 2Centre National de la Recherche Scientifique FRE 2445, Universite de Versailles/St Quentin, Versailles, France; 3Service d'Hematologie Biologique, U473, CHU Kremlin Bicetre, France; 4Laboratoire de Biochimie, Hopital Avicenne, APHP and EA 3406, Universite Paris 13, Bobigny, France; 5Laboratoire d'Hematologie, CHU Dupuytren, Limoges, France; 6Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, Leioa 48940, Bizkaia, Spain; 7Centre National de la Recherche Scientifique, UMR 5094, Montpellier, France N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a potent chemopreventive agent whose effect has been suggested to involve apoptosis induction. 4-HPR induces a loss of the mitochondrial transmembrane potential and the mitochondrial release of cytochrome c before caspase activation.

• hpr


• human ebv


• hydroxyphenylretinamide-induced mitochondrial apoptosis


• ccrf-cem cells


• mmp


• hpr-induced apoptosis


• caspase


• cell death


• inducing agent doxycyclin