MOLECULAR BIOLOGY OF SPEMANN'S ORGANIZER AND NEURAL INDUCTION ...

• cours magistral
• cours - matière potentielle : evolution

M267, March 2003 Lecture 5 Eddy De Robertis Page 1 MOLECULAR BIOLOGY OF SPEMANN'S ORGANIZER AND NEURAL INDUCTION - Lecture 5 Having discussed the early events in mesoderm induction, we now turn to signaling events that take place during gastrulation. . Dorsalization of mesoderm and neural induction by Spemann's Organizer during The “Organizer” experiment (Spemann and Mangold, 1924) is the best known experiment in e 1 gastrulation mbryology. It has led, more than any other, to the current view that development occurs through a cascade of cell-cell interactions.

• dorsalization of mesoderm
• chordin
• ventral regions of the gastrula
• early phase of chordin expression
• control grafts of dorsal lip into the dorsal region
• organizer
• bmp
• cns