Study Demonstrates Radioembolization Using SIR-Spheres Significantly Improves Overall Survival for Patients With Inoperable Colorectal Cancer

Study Demonstrates Radioembolization Using SIR-Spheres Significantly Improves Overall Survival for Patients With Inoperable Colorectal Cancer PR Newswire MAGDEBURG, Germany, October 21, 2012 MAGDEBURG, Germany, October 21, 2012 /PRNewswire/ -- Survival of patients treated with SIR-Spheres more than double that of patients who received best supportive care, benefit rivals that found with new biological agents, authors note The results of a matched-pair comparison of patients with metastatic colorectal cancer predominately affecting the liver, for whom all chemotherapy options had been exhausted, showed that the addition of radioembolization using SIR- [1]Spheres significantly prolonged survival compared with best supportive care (BSC) alone. http://photos.prnewswire.com/prnh/20121019/568108 The study, published in October's edition of Cardiovascular and Interventional Radiology, showed that median overall survival was more than doubled in patients receiving radioembolization plus BSC versus BSC alone: 8.3 months vs. 3.5 months (hazard ratio [HR] 0.26; 95% confidence interval 0.15-0.48; P500 patients who received BSC from 3 centres in Germany to identify 29 consecutive patients with at least 2 of 4 specific matching criteria (the presence of synchronous or metachronous metastases, tumour burden, increased alkaline phosphatase, and/or carcinoembryonic antigen [CEA] >200 U/mL). The primary endpoint of the study was overall survival.