A New Post Hoc Analysis Indicates asenapine has Effect on Both Manic and Depressive Symptoms in Bipolar I Disorder Patients Experiencing Mixed Episodes

A New Post Hoc Analysis Indicates asenapine has Effect on Both Manic and Depressive Symptoms in Bipolar I Disorder Patients Experiencing Mixed Episodes PR Newswire ECNP, VIENNA, October 15, 2012 ECNP, VIENNA, October 15, 2012 /PRNewswire/ -- Post hoc analyses presented at the 25th European College of Neuropsychopharmacology (ECNP) congress show asenapine achieves significant control of mixed episodes in bipolar I disorder compared to placebo. - For media outside China, Japan, UK, USA only. Lundbeck today announced results from post hoc analyses in bipolar I disorder patients experiencing mixed episodes, which found asenapine has a significant effect on both manic and depressive symptoms versus placebo. The analyses used pooled data from two identically designed 3-week, randomised, double-blind flexible dose, placebo- and olanzapine-controlled trials and a 9-week, double-blind olanzapine-controlled extension study. "One of the most challenging treatment goals in bipolar I disorder is to address mixed episodes, where both manic and depressive symptoms are present," said Professor Jean-Michel Azorin, Professor of Psychiatry at the Mediterranean University School of Medicine. "Mixed episodes are experienced by more than 40% of patients and are considered a severe presentation of bipolar I disorder. Further investigation into the potential to manage both depressive and manic symptoms simultaneously with one treatment is warranted.