Etude OGM

Séralini et al. Environmental Sciences Europe 2014, 26:14 http://www.enveurope.com/content/26/1/14 RESEARCH Open Access Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize 1* 1 1 1 1 2Gilles-Eric Séralini , Emilie Clair , Robin Mesnage , Steeve Gress , Nicolas Defarge , Manuela Malatesta , 3 1Didier Hennequin and Joël Spiroux de Vendômois Abstract Background: The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the diet), cultivated with or without Roundup application and Roundup alone (from 0.1 ppb of the full pesticide containing glyphosate and adjuvants) in drinking water, were evaluated for 2 years in rats. This study constitutes a follow-up investigation of a 90-day feeding study conducted by Monsanto in order to obtain commercial release of this GMO, employing the same rat strain and analyzing biochemical parameters on the same number of animals per group as our investigation. Our research represents the first chronic study on these substances, in which all observations including tumors are reported chronologically. Thus, it was not designed as a carcinogenicity study. We report the major findings with 34 organs observed and 56 parameters analyzed at 11 time points for most organs. Results: Biochemical analyses confirmed very significant chronic kidney deficiencies, for all treatments and both sexes; 76% of the altered parameters were kidney-related.