Aravind L

Savoirs

The signaling helix: a common functional theme in diverse signaling proteins

Anantharaman Vivek, Balaji S, Aravind, Aravind L

Savoirs

The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

Aravind L, Koonin

Savoirs

The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like β-grasp domains

Iyer, Burroughs, Aravind, Aravind L

Savoirs

Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes

Anantharaman Vivek, Aravind, Aravind L

Savoirs

Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

Makarova, Aravind L, Koonin, Wolf

Savoirs

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

Tasneem Asba, Iyer, Jakobsson Eric, Aravind, Aravind L

Savoirs

Small but versatile: the extraordinary functional and structural diversity of the β-grasp fold

Burroughs, Balaji S, Iyer, Aravind, Aravind L

Savoirs

Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors

Iyer, Koonin, Aravind, Aravind L

Savoirs

Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences

Iyer, Aravind L, Bork Peer, Hofmann Kay, Mushegian, Zhulin, Koonin

Savoirs

Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)

Shankavaram, Galperin, Aravind L, Koonin, Wolf, Natale

Savoirs

The PRC-barrel: a widespread, conserved domain shared by photosynthetic reaction center subunits and proteins of RNA metabolism

Anantharaman Vivek, Aravind, Aravind L

Savoirs

The GOLD domain, a novel protein module involved in Golgi function and secretion

Anantharaman Vivek, Aravind, Aravind L

Savoirs

A novel superfamily containing the β-grasp fold involved in binding diverse soluble ligands

Burroughs, Balaji S, Iyer, Aravind, Aravind L

Savoirs

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

Aravind L, Koonin

Savoirs

The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities

Aravind L, Iyer

Savoirs

Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions

Balaji S, Aravind, Venancio, Iyer, Aravind L

Savoirs

The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism

Aravind L, Iyer, Anantharaman, Anantharaman Vivek

Savoirs

New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system

Anantharaman Vivek, Aravind, Aravind L

Savoirs

A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain

Aravind L, Iyer, Leipe, Koonin